Erythroderma as first manifestation of squamous cell lung cancer: rare case report

Abstract Erythroderma as the first manifestation of a solid organ malignancy is rare. The underlying cancer is a challenging condition to diagnose. There are a few cases of erythroderma in cancer patients reported in the literature. We here describe the case of a 70-year-old man who presented with asthenia, weight loss, dry cough and total body erythema with desquamation over the past month. A chest computed tomography scan showed a nodular lesion, which was finally diagnosed as a squamous cell lung carcinoma. To our knowledge, as an erythroderma presentation, only 13 cases have been reported in the literature. This case report demonstrates the need to search for a neoplasm in patients presenting with erythroderma, particularly in the presence of accompanying debilitating symptoms.

Solar elastosis in conjunctival squamous cell neoplasm.

Aim: To study the role of solar elastosis in the patient's with Conjunctival Squamous Cell Neoplasia (CSCN). Materials and Methods: Paraffin embedded 30 Conjunctival Squamous Cell Neoplasia tissues were studied for the presence of solar elastosis by Verhoeff's stain. Nineteen Squamous Cell Carcinoma (SCC), 6 Carcinoma In Situ (CIS) and 5 Conjunctival Intraepithelial Neoplasia (CIN) specimens were included in the study. Disease free conjunctiva and pterygium tissues were used as negative and positive control respectively. Results: Solar elastosis was found to be present in 19 of 30 (63.3%) Conjunctival Squamous Cell neoplasia specimens. Conclusion: Our study showed the presence of solar elastosis in conjunctival squamous cell neoplasia. Poor socioeconomic condition is an important factor as most of the elastosis positive patients were farmers.

rare cause of small bowel transection: metastatic lung cancer

To present a case of small bowel perforation due to metastatic lung cancer. A 78-year-old male patient, who had been diagnosed with lung cancer 3 months earlier, presented to our clinic with acute abdominal pain. He underwent emergency laparotomy. At surgery, there was a circumferential lesion encompassing the ileum with complete transection. There was no obvious macroscopic appearance of metastatic disease. The involved bowel segment was resected and an ileostomy was performed. Postoperative pathologic analysis confirmed metastatic squamous cell carcinoma metastasis to the ileum, arising from the patient's lung cancer. This case report showed that small bowel metastases should always be considered in the differential diagnosis of lung cancer patients presenting with acute abdominal pain

Primary orbital aspergilloma of the exenterated orbit in an immunocompromized patient.

Aspergilloma is a fungal ball that usually forms in a preformed stationary cavity, mostly in lung and paranasal sinuses. We report a rare case of primary orbital Aspergilloma following exenteration for an invasive ocular surface squamous neoplasia, clinically mimicking a recurrence of the tumor. The fungal ball showed the presence of conidiophores with a globular head and a complete row of uni and biserrate phialides, suggestive of Aspergillus flavus species. The exposure to air in the orbit, possibly promoted the formation of conidiophores, which are normally seen when the organism is located in air cavities.

Valoración de pacientes con atipia escamosa de significado determinado / Valuation of patient with scaly atipia of meaning certain 2005 stage II

El presente estudio tiene como propósito conocer la evolución de pacientes con atipia escamosa de significado indeterminado captados en los centros de salud de la ciudad de León valorados en consulta externa de onco ginecología del Hospital Escuela Oscar Danilo Rosales Arguello (HEODRA), mediante valoración colposcópica y seguimiento posterior ya que estas son pacientes que ameriten intervención o al menos seguimiento estrecho hasta esclarecer un dignóstico. Se valoraron un total de 33 pacientes en la consulta externa el 53 porciento provenian de los centros de salud del casco urbano de León. En cuatno a los grupos de edades, la mayoría de pacientes estuvo entre las edades de 20 a 49 años. El 47 porciento de las pacientes estudiadas planifico con métodos hormonales y de estos el 13 porciento lo hizo por un período mayor de 5 años. El hábito de fumar y el número de compañeros sexuales parece no influir en la presencia de lesiones epiteliales de significado indeterminado, pero por el pequeño tamaño de la muestra estos resultados no son estadísticamente signficativos. En cuanto a la valoración colposcopica de estas pacientes, el 31 porciento tuvo algún grado de patrón colposcópico anormal que incluyó epitelio acetoblanco, punteado + epitelio acetoblanco y vasos atípicos en una zona de transformación anormal; esta valoración fue completada por la toma de biopsias selectivas a como lo ameritó cada caso. El 28 porciento de colposcopías presentaron modificaciones inflamatorias lo cual puede explicar la presencia atipica de origen reactiva en las muestras de Papanicolau. 22 porciento no se observó patrón colposcópico anormal. Existe una buena correlación entre la citología, los hallazgos colposcópicos y los resultados biológicos, ya que el 92 porciento de las biopsias dirigidas por colposcopía presentaron anormalidades que incluyen atipia y lesiones de alto o bajo grado...

Human papillomavirus prevalence, viral load and cervical intraepithelial neoplasia in HIV-infected women

HIV-infected women from S o Paulo city were enrolled in a cross-sectional study on Human Papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) prevalence and their association with laboratory markers of AIDS, namely HIV viral load and CD(4)(+) cell counts. A cervical specimen was collected and submitted to Hybrid Capture, a test for HPV viral load determination. HPV-DNA was detected in 173 of 265 women (64.5). Twenty (7.5) women were infected by one or more low-risk viruses, 89 (33) by one or more high-risk viruses, and 64 (24) harbored at least one HPV type from each risk group. Abnormal smears were observed in 19 of the patients, though there were no invasive carcinomas. Severely immunosuppressed patients (CD(4)/microL <100) were at the greatest risk of having a cytological abnormality and a high high-risk HPV viral load.